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Current Topics in Pharmacology   Volumes    Volume 1 
Disuse muscular atrophy: Influence of a pyrimidine nucleotide, the UTP, on the maintenance of histochemical and contractile properties
M. Falempin, Y. Mounier, D. Leterme, L. Stevens, C. Cordonnier
Pages: 23 - 32
Number of pages: 10
Current Topics in Pharmacology
Volume 1 

Copyright © 1992 Research Trends. All rights reserved

The objectives of this study were to examine the effects of a pyrimidine nucleotide, the UTP, on the contractile and histochemical properties of the rat soleus muscle. The UTP treatment consisted in injections into two types of muscles: control and atrophied muscles were used, the atrophy being induced by two weeks of hypokinesia-hypodynamia conditions (HH). The contractile properties were analyzed both on skinned fibers which permitted to have direct access to the contractile proteins and on in situ muscles. After HH, the slow soleus muscle appeared highly atrophied since the mass and tension values were significantly decreased. The analysis of its contractile and histochemical properties revealed that its typing became close to that of a fast muscle. When UTP was administrated to the control muscles, no significant change was found in the contractile parameters except a decrease in the half relaxation time. On the atrophied muscles, the tension decrease was counteracted by the administration of UTP. This result could be explained by a higher calcium affinity of the contractile proteins tested by the position of the Tension/pCa relationship. However, UTP did not prevent the kinetic changes linked to atrophy. The histochemical data and the fatigue index measurement indicated that, after a UTP treatment, the soleus muscle maintained its slow oxidative metabolism and endurance. For all the modified parameters, a UTP preventive treatment appeared more efficient than a curative one. Thus, a pyrimidine nucleotide such as UTP could be used as a contraction energetic supplier and might provide a means for the muscle to adapt to an atrophic situation.
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