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Trends in Photochemistry & Photobiology   Volumes    Volume 1 
Abstract
Increase in damaged-DNA binding and repair in human UV resistance
Chuck C.-K. Chao
Pages: 341 - 351
Number of pages: 11
Trends in Photochemistry & Photobiology
Volume 1 

Copyright © 1990 Research Trends. All rights reserved

ABSTRACT
 
A human cell line selected for cisplatin resistance (CPR) was irradiated with ultraviolet (UV) and it showed cross resistance to UV. Applying modified CAT assay, we observed that CPR cells acquired enhanced host cell reactivation of transfected plasmid carrying UV damage. Gel mobility shift analyses indicate that two nuclear factors that recognize UV modified DNA (UVMD) were overexpressed in CPR cells. In addition, UVMD binding factors are independent from the factors that bind cisplatin modified DNA (CMD). The significance of the identified damage DNA binding factors, possibly DNA repair enzymes, is discussed.
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