Peanut (Arachis hypogaea L.) pod yield and response to early and late leaf spot (caused by Cercospora arachidicota S. Hori and Cercosporidium personatum (Berk. & M.A. Curtis) Deighton, respectively) were evaluated on four cultivars: Florunner, GK-7, Southern Runner, and Sunrunner under four leaf spot spray programs using tebuconazole at 0.58 L/ha in combination with chlorothalonil at 1.75 L/ha. The four leaf spot spray programs included unsprayed, 14-day schedule, 21-day schedule, and 28-day schedule. Under conditions of heavy leaf spot disease pressure where no fungicide was applied, Southern Runner had 8-11% less leaf spot late-season than other cultivars. Less leaf spot was present in the 14-day spray schedule plots compared to 21- or 28-day spray schedule plots. There was no differences in yield across cultivars between 14-, 21-, and 28-day spray schedules; however, these yields were greater than those from the untreated check.