Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Immunology   Volumes    Volume 1 
Abstract
Regulation of human B lymphocyte responsiveness by activated CD4+ T cells
Shunsei Hirohata
Pages: 41 - 56
Number of pages: 16
Current Trends in Immunology
Volume 1 

Copyright © 1998 Research Trends. All rights reserved

ABSTRACT
 
Human activated CD4+ T cells have been shown to provide helper signals to resting B cells to express CD25 and CD71 as well as exert suppressive influences on the proliferation and differentiation of activated B cells. It has been also demonstrated that activated T cells provide helper signals to resting B cells through direct cellular interactions, mainly mediated by CD40-CD40 ligand (CD40L) interactions. It was also disclosed that the suppression of human B cell responses by activated CD4+ T cells requires direct cellular interactions between B cells and T cells. Human B cells express functional Fas receptor on activation through CD40 ligation and become sensitive to Fas mediated apoptosis. In fact, apoptosis indicing anti-Fas mAb suppresses the Ig production of B cells activated through CD40 ligation. However, neither neutralizing anti-Fas mAb nor anti-FasL mAb reversed the suppressive influences of anti-CD3-activated CD4+ T cells on B cell responses, suggesting that the interactions other than those mediated through Fas and FasL might also play a critical role in the suppression of B cell responses by activated human T cells. Apart from the positive impact on B cell responses, there have been several lines of evidence that CD40-CD40L interactions deliver negative signals to human B cell responses. Accordingly, our recent studies have clearly shown that anti-CD40L almost completely reversed the suppressive influences of anti-CD3-activated CD4+ T cells on the Ig production on human peripheral blood B cells, thus supporting the hypothesis that CD40-CD40L interactions play a critical role in the suppression of B cell responses by activated CD4+ T cells. Collectively, these observation lead to a conclusion that CD40-CD40L interactions between B cells and CD4+ T cells are bidirectional and that the state of activation of B cells and the extent of CD40 engagement on B cells are important in determining the direction of signals.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms