Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Immunology   Volumes    Volume 1 
Abstract
Cytokine profile of autoreactive T lymphocytes in Multiple Sclerosis and experimental autoimmune encephalomyelitis
Guy Hermans, Leen De Ryck, Jef Raus, Piet Stinissen
Pages: 69 - 78
Number of pages: 10
Current Trends in Immunology
Volume 1 

Copyright © 1998 Research Trends. All rights reserved

ABSTRACT
 
Myelin reactive T cells are considered to play an important role in the pathogenesis of Multiple Sclerosis (MS). This is partially based on observations in the animal model of MS, experimental autoimmune encephalomyelitis (EAE), that myelin reactive T cells can transfer the disease to native rodents. Recent data in EAE suggest that encephalitogenic and non-encephalitogenic myelin reactive T cells differ with respect to their cytokine secretion profile: pathogenic myelin reactive T cells express a Th1 phenotype, while non-pathogenic T cells preferentially produce Th2 cytokines. To study whether similar subsets can be identified in human myelin reactive T cells, the cytokine profile of a panel of myelin basic protein reactive T cell clones from MS patients and control subjects was evaluated. Most of the MBP reactive clones expressed pro-inflammatory cytokines, but did not show a clearly defined Th1 phenotype. In this paper current data on the cytokine profile of murine and human myelin reactive T cells from our laboratory and other groups will be reviewed. The relevance of these findings with respect to the pathogenesis and possible cytokine based therapies in MS will be discussed.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms