Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Virology   Volumes    Volume 1 
Cytokine/chemokine networks in the pathogenesis of HIV disease: implications on therapeutic interventions
Hiroyuki Moriuchi, Masako Moriuchi
Pages: 229 - 233
Number of pages: 5
Current Topics in Virology
Volume 1 

Copyright © 1999 Research Trends. All rights reserved


Host factors have a great influence on the susceptibility to HIV or the rate of HIV disease progression. In particular, cytokine/chemokine networks have been shown to variably modulate HIV infection. Of note are the facts that certain chemokine receptors serve as HIV entry coreceptors and that ligands for these receptors inhibit HIV infection through competition for the coreceptors. The effects of pleiotropic cytokine/ chemokine networks on HIV infection, however, appear to be dependent on the virus strains and the cell types being infected. Certain cytokines/chemokines have dichotomous effects on infection with macrophage-tropic and T-cell-tropic HIV-1, or differently modulate HIV infection of macrophages, as compared to that of CD4+ T cells. A further investigation of roles of cytokine/ chemokine networks in HIV infection and delineation of the mechanisms of the cytokine/ chemokine-mediated effects on HIV infection will extend our understanding of the pathogenesis of HIV disease, and may yield novel therapeutic strategies for intervention in HIV disease.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms