A new trend in reproductive biology is to research advancements in medical care for the preimplantation patient on the basis of new technologies. Based on the size parameters of the preimplantation patient, the technologies of interest fall predominately under the head of integrated microfabrication technologies (IMT). Such technologies are able to produce integrated electrical, mechanical, and chemical systems and devices at the submillimeter, micrometer (micron), and nanometer scale. A few examples of IMT technologies include micro-electro-mechanical systems (MEMS), complementary metal oxide semiconductor (CMOS) technology, and nanotechnology. By employing microfabrication technologies in combination with large-scale technologies, the medicine-of-the-future will be able to care for the preimplantation patient in a sophisticated micro-milieu. A tragic fault of in vitro fertilization programs today is that most practitioners rely unimaginatively on crude laboratory dish methods suitable only for primitive biological specimens. Consequently, morbidity and mortality rates are extremely high in these programs. Of particular concern is that programs based on a crude laboratory paradigm do not account for the actual body temperature of the preimplantation patient. For this reason, such programs do not offer accurate thermoregulation of the body temperature. However, accurate thermoregulation forms the basis of a competent incubator system. To provide accurate thermoregulation, an advanced incubator care system is needed which uses the techniques of infrared microthermography to  monitor  body   temperature. On this basis a new breed of incubator is emerging for the preimplantation patient—known as the prenidial (“pre-NID-e-al”) incubator, a word derived from pre-nidation.