ABSTRACT The aldol reaction is a powerful means of forming carbon-carbon bonds in organic chemistry. The reaction combines two carbonyl compounds to form a new β-hydroxy carbonyl compound. Over the past few years, rapid progress has been made in the development of the organocatalyzed aldol reaction. Organocatalysts are simple organic molecules that mimic enzymes in catalyzing the aldol reaction leading to enantiomerically enriched compounds. However, despite its efficiency and low cost, high catalyst loading is often required for high conversions. Hence, heterogenization of the homogeneous organocatalysts appeared to be a promising method for recyclability with simple workup by filtration and washing. This review entails various chiral organocatalysts immobilized on polymer, dendrimers, silica and ionic liquids, and their application in the asymmetric aldol reaction.
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