The high affinity IgE receptor (FcεRI) has been shown to be present not only on the surface of mast cells and basophils as initially thought, but also on monocytes, platelets, eosinophils, dendritic and Langerhans cells. Contrary to the widely accepted paradigm that binding of IgE to FcεRI is a passive pre-sensitization step, recent reports have demonstrated IgE alone to mediate a spectrum of effects including a significant survival effect on mast cells and monocytes through binding to FcεRI. We previously showed that a subpopulation of peripheral blood neutrophils from allergic asthmatic individuals express FcεRI that is functionally capable of binding to IgE. Recently, we demonstrate an anti-apoptotic effect exerted by monomeric IgE on neutrophils and propose that this might act as a potential mechanism contributing to accumulation and subsequent activation of neutrophils in allergic asthma.