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Current Topics in Virology   Volumes    Volume 10 
Abstract
Interferon alpha therapy for classic Kaposi’s sarcoma: A 5-year follow-up
Alexandra Monastirli, Efi Pasmatzi, Sophia Georgiou, George Sgouros, Dionysios Tsambaos
Pages: 17 - 22
Number of pages: 6
Current Topics in Virology
Volume 10 

Copyright © 2012 Research Trends. All rights reserved

ABSTRACT
 
The therapeutic efficacy and safety of subcutaneously applied recombinant interferon alpha (IFN-α) at doses of 6X106 IU/day (3 times/week) were investigated in 26 patients with classic Kaposi’s sarcoma. After a 6-month IFN-α administration 18 patients (69.23%) revealed a complete remission, 4 patients (15.38%) showed a partial remission and 4 patients (15.38%) were non responders. 12 out of 18 patients (66.66%) with complete remission relapsed within 23-46 months after discontinuation of therapy. Recurrences revealed an impressive therapeutic response to IFN-α requiring short periods of retreatment (6-10 weeks) with the same dosage. 6 patients (33.33%) are presently completing a 68-84 month follow-up without any evidence of recurrence. All patients but one revealed a transient flu-like syndrome including fever, fatigue, chills, headache and myalgias that were treated with paracetamol. Apart from a transient leukopenia observed in all patients but one and a transient neutropenia seen in 3 patients, no significant changes of laboratory parameters were observed. These findings indicate that the subcutaneous application of IFN-α represents an effective, easy to perform and well tolerated therapeutic approach to the classic form of Kaposi’s sarcoma, that leads to long remissions of the disease in a considerable number of patients, whereas recurrences are highly responsive to short periods of retreatment.
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