Modelling the equilibrium conformations of proteins by computer is a major issue in the post-genomic era. Current bioinformatics methods fail to provide a three-dimensional structure for more than half of the proteins from the fully sequenced genomes. In order to provide structural candidates for these genes, a number of sampling methods for protein folding are being developed. Here, we describe in detail recent promising protein folding models using molecular dynamics simulations, genetic and Monte Carlo-based methods.