Clinical toxicology, mainly the diagnosis and treatment of acute poisonings, represents 2-3% of hospital emergencies. We analysed the relationship between clinical toxicology and emergency medicine in Spain by reviewing toxicological articles published in EMERGENCIAS, the official journal of the Spanish Society of Emergency Medicine, in the last 25 years. After accessing the EMERGENCIAS website (http://www.semes.org/revista_EMERGENCIAS/english), we read all the titles of articles published between 1988 and 2013 and identified articles containing the words toxic, intoxication, poisoning or any potentially-poisonous source including medicines, drugs of abuse, domestic, agricultural or industrial products, plants, fungi and animals. Adverse reactions to medications and foodborne infections were excluded. We extracted the main characteristics of each article identified. Articles selected were grouped in five-year periods to analyse the temporal evolution. Twenty-five volumes (154 numbers) of EMERGENCIAS, with 2160 articles, were reviewed. We identified 192 (8.9%) articles on toxicology, including Letters to the Editor (57 documents), Original or Short original articles (54 documents) and Clinical notes (31 documents). There were no significant differences (p > 0.05) according to five-year periods, the proportion of toxicological articles published or the type of article. Of the articles selected, 86.4% were of hospital origin, 9.4% involved nurses as authors, 9.6% were related to children and 47% came from Madrid or Barcelona. Intoxication due to medications and drugs of abuse were the most prevalent subjects. In recent years there has been a significant decline in articles on intoxication due to medications (p < 0.001), and there have been more articles on drugs of abuse and with the collaboration of ≥ 2 centres (p < 0.001). In conclusion, clinical toxicology has been uniformly represented in EMERGENCIAS in the last 25 years, confirming the ongoing relationship between Spanish toxicologists and emergency physicians. Most articles came from hospitals and referred to medications and drugs of abuse.