Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Toxicology   Volumes    Volume 10 
Update on the oxidative stress associated with arsenic exposure
Julián G. Bonetto, Edda C. Villaamil Lepori, Susana Puntarulo
Pages: 37 - 48
Number of pages: 12
Current Topics in Toxicology
Volume 10 

Copyright © 2014 Research Trends. All rights reserved

Even though oxidative stress is currently widely accepted as a factor in As toxicity in both the liver and kidney, the mechanisms are not yet clearly understood. It has been suggested that As may induce oxidative stress by cycling between oxidation states of metals such as Fe, or by interacting with antioxidants and increasing inflammation, resulting in the accumulation of free radicals in cells. Major As-induced reactive oxygen species (ROS) include superoxide anion (O2), hydroxyl radical (·OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), and peroxyl radicals. On the other hand, molecular oxygen reacts with dimethylarsine (a trivalent As form and a minor in vivo metabolite of dimethylarsinic acid) to form dimethylarsinic radical and O2ˉ. Further, the addition of another molecule of molecular oxygen may result in a dimethylarsinic peroxyl radical and these As radicals are known to be detrimental to cells. It has been shown that As induced free radical formation in mouse livers. Experimental results have shown the generation of O2ˉ and H2O2 after As exposure in some cell lines such as human vascular smooth muscle cells, human-hamster hybrid cells, and vascular endothelial cells. Whereas, induction of H2O2 have been shown in other cell lines such as HEL30, NB4, and CHOK1 after exposure to As. The objective of the present review is to summarize the current knowledge on the role of oxidative stress in As toxicity in brain.

View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms