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Trends in Cell & Molecular Biology   Volumes    Volume 10 
The spindle assembly checkpoint: More than just keeping track of the spindle
Katherine S. Lawrence, JoAnne Engebrecht
Pages: 141 - 150
Number of pages: 10
Trends in Cell & Molecular Biology
Volume 10 

Copyright © 2015 Research Trends. All rights reserved

Genome stability is essential for cell proliferation and survival. Consequently, genome integrity is monitored by two major checkpoints, the DNA damage response (DDR) and the spindle assembly checkpoint (SAC). The DDR monitors DNA lesions in G1, S, and G2 stages of the cell cycle and the SAC ensures proper chromosome segregation in M phase. There have been extensive studies characterizing the roles of these checkpoints in response to the processes for which they are named; however, emerging evidence suggests significant crosstalk between the checkpoints. Here we review recent findings demonstrating overlapping roles for the SAC and DDR in metaphase, and in response to DNA damage throughout the cell cycle.
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