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Current Topics in Peptide & Protein Research   Volumes    Volume 11 
Abstract
Ceratotoxins, antibacterial sex-specific peptides from the medfly Ceratitis capitata
Daniela Marchini, Laura Marri
Pages: 31 - 36
Number of pages: 6
Current Topics in Peptide & Protein Research
Volume 11 

Copyright © 2010 Research Trends. All rights reserved

ABSTRACT
 
Ctxs are a family of α-helical, cationic, 3 kDa antibacterial peptides secreted by the female reproductive accessory glands of the Mediterranean fruit fly Ceratitis capitata. These peptides were found to display strong antibacterial activity and weak hemolytic activity. When reconstituted into planar lipid bilayers chemically synthesized Ctxs formed voltage-dependent ion channels according to the barrel-stave model. A synthetic truncated CtxA molecule resulted to permeabilize the outer and inner membranes of Escherichia coli cells.
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