Chiral enantiopure mono- and bis-sulfonamides have found wide application in asymmetric catalysis. They have been successfully applied in the alkylation of aldehydes, asymmetric transfer hydrogenation of aromatic ketones, aldol reactions, Diels-Alder reaction, Simmons-Smith cyclopropanation, α-oxidation, α-aminoxylation of carbonyl compounds and as organocatalysts in the asymmetric Michael addition. This review details the usefulness of these ligands and the mechanisms involved in inducing chirality.