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Current Topics in Peptide & Protein Research   Volumes    Volume 12 
Abstract
β-amyloid peptide in pathogenesis of Alzheimer’s disease
S. Chieffi, M. La Marra, G. Messina, V. De Luca, A. Messina, M. Monda
Pages: 65 - 69
Number of pages: 5
Current Topics in Peptide & Protein Research
Volume 12 

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
Alzheimer’s disease is a debilitating form of dementia which currently affects at least 30 million people worldwide. For many decades, the prevailing hypothesis on the pathogenesis of Alzheimer’s disease has involved the gradual buildup of β-amyloid plaques in the brain. Recent evidence suggests that soluble oligomers assemblies of β-amyloid are neurotoxic and responsible for the synaptic and memory dysfunction. Herein, we review the main researches on the mechanisms through which β-amyloid oligomers exert their toxic action.
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