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Current Topics in Peptide & Protein Research   Volumes    Volume 12 
Abstract
Caffeine protection against β-amyloid peptide toxicity in Alzheimer’s disease
S. Chieffi, M. La Marra, A. Viggiano, G. Messina, V. De Luca, M. Monda
Pages: 71 - 75
Number of pages: 5
Current Topics in Peptide & Protein Research
Volume 12 

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
Alzheimer’s disease is the most common chronic neurodegenerative disease clinically characterized by a progressive impairment of cognitive function. The neurochemical parameter best correlated with cognitive dysfunction is the level of soluble β-amyloid peptide. Experimental evidence suggests that caffeine afford a robust protection against β-amyloid peptide toxicity. We discuss the mechanisms through which caffeine prevents cerebral β-amyloid peptide toxicity.
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