ABSTRACT The present review focuses on the synthesis of heterocyclic systems contained the basic core of 1H-azepine-2,5-dione and derivatives of it, fused with aryl or/and heteroaryl rings such as pyrrole, thiophene and indole. A survey of the synthetic methodologies that have been appeared in the literature between 1978 and 2006 is presented and emphasis is placed on derivatives with potential biological activities.
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