Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Microbiology   Volumes    Volume 12 
Bioactive agents as modulators of multidrug efflux pumps of the major facilitator superfamily in key bacterial pathogens
Ugina Shrestha, Manjusha Lekshmi, Sanath Kumar, Jones Adjei, Krista M. Jones, Alberto J. Hernandez, Leslie M. Sanford, Manuel F. Varela
Pages: 15 - 37
Number of pages: 23
Current Trends in Microbiology
Volume 12 

Copyright © 2018 Research Trends. All rights reserved

Infectious disease-causing bacterial pathogens that harbor multidrug resistance may be difficult to treat effectively. Such bacterial pathogens may possess an assortment of cellular mechanisms, such as antimicrobial resistance, for conferring virulence and infectious disease. One major antimicrobial resistance mechanism involves the extrusion of growth inhibitory substances from the internal milieu of the pathogenic bacterium. Several transporter superfamilies have emerged as being chiefly responsible for the efflux of multiple antimicrobial agents from bacteria. Of these protein superfamilies, the so-called major facilitator superfamily (MFS) of solute transporters encompasses several key and well-studied multidrug efflux pump systems. These multidrug transporters of the superfamily are, thus, excellent targets for modulation. Of the various drug efflux pump modulators which have been discovered so far, those that are relatively non-toxic to humans are obviously the most promising modulatory candidates. This review article briefly summarizes several key bacterial pathogens and modulation targets exemplified by multidrug efflux systems of the major facilitator superfamily.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms