Photocatalytic degradation of polyvinyl-pyrrolidone (PVP) was studied by the system TiO₂/H₂O₂/UV in an annular batch photoreactor. PVP solutions were tested under different conditions using a 2⁴ full factorial design. The monitoring of the degradation was evaluated by measurements of total organic carbon (TOC) and chemical oxygen demand (COD). Measurements of residual H₂O₂ concentration were also performed. The results indicated that the studied process is promising and can achieve mineralization rates of about 80% by utilizing appropriate initial concentrations of PVP, catalyst dosage and hydrogen peroxide concentration, at pH 4 or 7.