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Trends in Cell & Molecular Biology   Volumes    Volume 13 
Safeguarding of pre-mRNA splicing by Prp4 kinase is based on formation of transient structures
Nicole Andrée-Busch, Daniela Eckert, Susanne Zock-Emmenthal, Norbert F. Käufer
Pages: 57 - 66
Number of pages: 10
Trends in Cell & Molecular Biology
Volume 13 

Copyright © 2018 Research Trends. All rights reserved

In fission yeast, Prp4 kinase activity is required for recognition of introns with weak splice sites. In this context, we analyzed the consequences of mutations within the branch sequence. We found that only changes in the nucleotide transiently interacting with a pseudouridine in snRNA U2 and one double mutation in the branch sequence lead to the requirement of Prp4 kinase activity. The results presented here and previously let us propose that Prp4 kinase activity is part of a safeguarding process that facilitates formation of transient RNA duplexes between pre-mRNAs and snRNAs to form the pre-spliceosome.
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