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Current Topics in Virology   Volumes    Volume 14 
Abstract
Cervical tissue-based organ culture as a model to study HIV-1 transmission
Phalguni Gupta, Anwesha Sanyal
Pages: 39 - 46
Number of pages: 8
Current Topics in Virology
Volume 14 

Copyright © 2017 Research Trends. All rights reserved

ABSTRACT
 
Sexual transmission via vaginal intercourse accounts for majority of human immunodeficiency virus type 1 (HIV-1) in women. The mechanism by which HIV-1 traverses the tightly bound tissue structure of cervical/vaginal epithelium, especially when vaginal/cervical epithelial cells do not express HIV-1 receptor or co-receptors is still unknown. With the restrictions on studying these mechanisms in humans and the substantial anatomical differences between human and non-human primates, investigators have used cervical tissue-derived organ culture models that closely mimic the human in vivo environment to study HIV-1 transmission. This report reviews our current knowledge of various cervical tissue-derived organ cultures and their application in studying HIV-1 transmission and microbicide development.
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