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Current Topics in Biotechnology   Volumes    Volume 14 
Abstract
Two polar contacts between GLU290 and ARG4 linking the two monomers of SARS-CoV-2 3CLpro
Jiapu Zhang
Pages: 19 - 33
Number of pages: 15
Current Topics in Biotechnology
Volume 14 

Copyright © 2023 Research Trends. All rights reserved

ABSTRACT
 
We have found that in common, from almost all the models of the SARS-CoV-2 3CLpro dimer, there are two polar contacts between GLU290 and ARG4 linking the two monomers. This article is to confirm this observation from optimization and molecular dynamics analyses of the open access molecular dynamics trajectory databases (zenodo.org/record/7401989) of the 3CLpro-monomer/dimer without ligand. All the hydrogen bonds linking the two monomers are also worth keeping our eyes open.
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