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Trends in Entomology   Volumes    Volume 15 
Reconsideration of the abnormal larval behaviors used to characterize a strain, lemon lethal, of the silkworm Bombyx mori as a model of Parkinson’s disease
Hiroaki Abe
Pages: 123 - 129
Number of pages: 7
Trends in Entomology
Volume 15 

Copyright © 2019 Research Trends. All rights reserved

A mutant strain of the silkworm Bombyx mori (L.) (Lepidoptera: Bombycidae) has been proposed as a model for Parkinson’s disease. The larvae of homozygous lemon lethal (leml) mutants, deficient in sepiapterin reductase, are reported to show abnormal behaviors such as head shaking and feeding inability after the first ecdysis. It was observed that although the leml/leml larvae had an appetite, they could not bite off pieces of mulberry leaves because of their abnormally soft mandibles. Further observations of leml/leml larvae revealed normal movement. Taken together, these data indicate that the leml strain is not suitable for use as a Parkinson’s disease model.
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