This short review explores the development of paper-based devices in chemical detection, emphasizing their potential for transforming health monitoring, environmental sensing, and point-of-care diagnostics. These devices, characterized by their low-cost production, biodegradability, and ease of use, are revolutionizing the way we approach chemical detection. In health monitoring, they facilitate the non-invasive tracking of vital biomarkers, offering new insights into individual health statuses without the need for invasive procedures. In the environmental sector, their application in detecting pollutants and hazardous gases provides a sustainable, effective tool for monitoring air and water quality, crucial for public health and safety. The article further explores how these devices are breaking barriers in point-of-care diagnostics, enabling rapid, onsite testing that is especially valuable in resource-limited settings. By highlighting the latest advancements and applications, this paper underscores the versatility and potential of paper-based sensors in addressing global health and environmental challenges, paving the way for more accessible and sustainable diagnostic solutions. In addition, the manuscript serves to identify key gaps in the field to address in future research.