The validation of analytical methods and equipment calibration is a very important aspect to ensure quality in a chemistry laboratory. Any method that is introduced in a laboratory must be properly documented, and all analysts using that new methodology must receive adequate training and demonstrate their competency in the new method before beginning to use it in any analysis. New analytical methods, like laser-induced breakdown spectroscopy (LIBS), also need revalidation or at least verification. If a method is modified or applied to a new situation (e.g., a different sample matrix), revalidation or verification would be required depending on the extent of the modification and the nature of the new situation. In this work, a set of protocols for the analysis by LIBS of different samples are presented. These cases can be taken as examples to develop more complex systems to prepare guidance for the validation of analytical methodology and calibration of LIBS equipment used in analytical chemistry. The LIBS community should provide support to laboratories in introducing and implementing a quality management system to include LIBS as a common standard analytical method.