Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Immunology   Volumes    Volume 15 
Abstract
Role of macrophages in the immunopathogenesis of type 1 diabetes mellitus
Ivan H. Chan-Zapata, Rosalinda A. Escalante-Caballero, Jaqueline Canul-Canche, Julio C. Torres-Romero, Victor E. Arana-Argaez
Pages: 59 - 66
Number of pages: 8
Current Trends in Immunology
Volume 15 

Copyright © 2014 Research Trends. All rights reserved

ABSTRACT
 
Diabetes mellitus is a syndrome characterized by insulin deficiency that leads to hyperglycemia. There are four major types of diabetes mellitus, including type 1. The type 1 diabetes mellitus results from destruction of pancreatic β-cells, usually leading to absolute insulin deficiency. The inflammatory lesion within islets related to type 1 diabetes mellitus (called insulitis) is typically characterized by a decrease (or absence) of insulin-producing β-cells along with a pancreatic islet cell infiltrate, composed of macrophages and other cells that represent the immune response. Macrophages are found in all tissues and show great functional diversity. They have roles in development, homeostasis, tissue repair and immunity. It has been shown that macrophages play an important role in type 1 diabetes mellitus: uptake, processing and presentation of antigens to T-lymphocytes and regulation of T-lymphocyte-driven responses through cytokine release. In this article, we review recent insights into the role of macrophages with regard to their functions and importance as antigen-presenting cells in type 1 diabetes mellitus.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms