Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Virology   Volumes    Volume 15 
Divergence from canon: an additional opportunity for alphavirus entry
Ryan M. Schuchman, Dennis T. Brown, Raquel Hernandez
Pages: 1 - 11
Number of pages: 11
Current Topics in Virology
Volume 15 

Copyright © 2018 Research Trends. All rights reserved

The study of animal virus entry is a very difficult endeavor with many obscurities; thus the field of virology finds itself with vast chasms of disagreement on this topic. To further complicate this difficulty, characteristics specific to each virus system combine to make experimental interpretation difficult. For example, a virus species may be programmed to enter through differing pathways depending on the cell type and host species of cell that it infects. Further, viruses can characteristically have high particle-to-plaque-forming unit (PFU) ratios that make observations by direct means difficult to interpret. These problems have plagued the field of virology for many years and will likely persist into the foreseeable future until methods and technologies advance to allow for increased resolution of these scientific impasses. This review will attempt to highlight the history, methodologies, and new developments within the field of alphavirus biology in the context of both receptor-mediated endocytosis and direct penetration hypotheses of virus penetration. Additionally, comparisons will be made between the proposed entry mechanisms of Alphaviruses, and other enveloped viruses that may not follow orthodox pathways, to demonstrate the technical problems encountered by these studies.


View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms