Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Trends in Microbiology   Volumes    Volume 15 
Abstract
Immunomodulatory effect of Lepidium meyenii (Peruvian maca) in the inflammatory response of human macrophages to mycobacteria
Habiba Khan, Jose Barragan, Esdras Rodriguez, Carlos Machuca-Hernandez, Jessica Hungate, Piya Kositangool, Jorge L. Cervantes
Pages: 71 - 77
Number of pages: 7
Current Trends in Microbiology
Volume 15 

Copyright © 2021 Research Trends. All rights reserved

ABSTRACT
 
Lepidium meyenii (Lm), also known as maca, is an Andean crop used medicinally for multiple purposes. Studies have shown an immunomodulatory anti-inflammatory effect in murine macrophages, able to induce M1 macrophage polarization. We aimed to assess the effect of Lm on the inflammatory response of human macrophages to mycobacteria. Human monocytic THP-1 cells bearing two plasmid reporter systems for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and interferon regulatory factor (IRF) activation, were differentiated into macrophages with Phorbol 12-myristate 13-acetate (PMA), and then treated with Lm at concentrations of 1 ug/ml, 5 ug/ml and 10 ug/ml for 48 hours. Cells were then stimulated with Mycobacterium tuberculosis (Mtb), Mycobacterium smegmatis, and bacillus Calmette-Guérin (BCG) for 24 hours. Lm-pre-treated cells showed a reduction in the NF-kB activation upon inoculation with Mtb, M. smegmatis, and BCG, in a dose-dependent manner. No effect was observed in IRF activation. Lm decreased the amount of internalized Mtb, while increasing the number of BCG in human macrophages. Lm treatment at small doses lead to an M1 macrophage polarization. Our results indicate that Lm exerts an immunomodulatory effect on the NF-kB activation of human macrophages upon mycobacteria challenge. These findings could translate into a potential use of Lm in conditions of exacerbated inflammatory response such as cases of BCGitis or complications due to excessive inflammation during intravesical BCG therapy.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms