More than a year into the pandemic of severe acute respiratory syndrome-related Corona virus-2 (SARS-Cov-2), there is a growing body of evidence for the involvement of the virus in the nervous system by different mechanisms. Here we report on a previously healthy 39-year-old man who presented with clinical symptoms suggesting encephalitis including fever, impaired consciousness, confusion, and seizures. Cerebrospinal fluid analysis confirmed the diagnosis. Repeated serological tests were positive for IgM and IgG to SARS-Cov-2 despite negative polymerase chain reaction (PCR) test result for the virus in the nasopharyngeal swabs and CSF samples. An extensive work-up for other infectious, inflammatory, or paraneoplastic causes was negative. The patient was intubated and sedated due to impaired consciousness and received supportive treatment. The patient was extubated after 3 days and recovered gradually over 3 weeks. This case suggests the development of post-infectious encephalitis due to previous Covid-19 infection, like the development of post-infectious encephalitis after infection with other viruses.