ABSTRACT Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two common neurodegenerative diseases of elderly people, so far known, that have devastating effects in terms of morbidity and mortality. They manifest cognitive and motor disorders, respectively, and in either case the disease is sporadic with uncertain etiology. In terms of molecular pathogenesis, however, both the diseases have a significant commonality, and proteinopathy (abnormal accumulation of misfolded proteins); mitochondrial dysfunction and oxidative stress are the cardinal features in either case. Understanding the common nature of these interactions may, therefore, help us to identify putative neuro-protective strategies that would be beneficial in both the clinical conditions. Here we will focus on the importance and possibilities of using modified neural stem cells for the cell therapy of both diseases.
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