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Current Topics in Toxicology   Volumes    Volume 15 
Protective effect of nettle (Urtica doica L.) against dimethoate-induced alterations in the liver and spleen of Wistar rats
Majda Samih, A. O. T. Ahami
Pages: 75 - 79
Number of pages: 5
Current Topics in Toxicology
Volume 15 

Copyright © 2019 Research Trends. All rights reserved

Stinging nettle has been shown to have antioxidant potential that plays a role in the prevention of hepatotoxicity. The purpose of this study is to explore the protective effect of this medicinal plant against dimethoate-induced liver and spleen injury in male rats. For this, we took forty male Wistar rats and divided them into two groups of 20 animals each. The first group A was used as the control. The second half was divided into two subgroups B and C. These two subgroups were designed to receive dimethoate dissolved in corn oil at a dose of 100 mg/kg body weight daily via gavage, while control A received only corn oil. Parallel to the intoxication, the subgroup B had free access to drinking water, and the animals of C received a decoction of the nettle at will. At the end of the treatment period, the effect on liver weight was recorded and the livers and spleen tissues were analyzed with an optical microscope. The results showed that there was a significant reduction in liver weight in the various components of subgroup B as well as several histopathological changes in the organs analyzed. In subgroup C, there was a slight decrease in body weight compared to the control, but the liver and spleen tissues retained their architecture without significant change. In conclusion, the decoction of nettle showed its effectiveness and protective role against poisoning, especially that induced by dimethoate.
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