Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Pharmacology   Volumes    Volume 16 
Abstract
P2 receptors - promising targets for future drugs
Ayrat U. Ziganshin, Bulat A. Ziganshin
Pages: 45 - 51
Number of pages: 7
Current Topics in Pharmacology
Volume 16 

Copyright © 2012 Research Trends. All rights reserved

ABSTRACT
 
P2 receptors, where ATP is the main endogenous agonist, are widely distributed in human tissues and deserve significant interest as potential drug targets. Based primarily on our own results, in this review we discuss some possible directions for such drug development. We have suggested that P2 receptors are upregulated in human uterus during pregnancy and involved in physiological labor, while low concentration of ATP can potentiate the uterotonic activity of prostaglandins in labor. Cardiodepressant activity of ATP is more pronounced at low temperature, which draws attention to drug action (and interaction) during hypothermic cardiac surgery. P2 receptor-mediated vasoconstrictive effect is decreased in varicose veins, which opens up a promising field for development of new venotonic drugs.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms