Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 16 
Effect of Cannabis sativa on the silymarin-induced hepatoprotection in the rat
Omar M. E. Abdel-Salam, Marwa El-Sayed El-Shamarka, Nermeen Shafee
Pages: 83 - 98
Number of pages: 16
Current Topics in Pharmacology
Volume 16 

Copyright © 2012 Research Trends. All rights reserved

Cannabis sativa preparations are the most widely used illicit drugs worldwide. Silymarin or milk thistle is a widely used hepatoprotective agent. The present study examined the possible modulation by Cannabis sativa preparation of the hepatoprotective effect of silymarin. Mice were pretreated with Cannabis sativa extract (10 or 20 mg/kg; expressed as Δ9-tetrahydrocannabinol), silymarin (25 mg/kg) or cannabis combined with silymarin for 5 days prior to the administration of carbon tetrachloride (CCl4) and mice were euthanized 24 h post-CCl4. Alternatively, cannabis alone (20 mg/kg) or cannabis combined with silymarin (25 mg/kg) was given simultaneously with CCl4 and mice were euthanized 5 days later. Liver damage was assessed by determining hepatic enzyme activities and hepatic histopathology. Malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (the concentrations of nitrite/nitrate) and paraoxonase (PON 1) activity were determined in the liver. Results indicated that mice pretreated with silymarin showed significantly increased GSH, decreased MDA, nitric oxide as well as liver transaminases. Cannabis sativa given prior to CCl4 resulted in increased liver nitric oxide and transaminases, but failed to alter GSH or PON1 activity. In contrast, cannabis given simultaneously with CCl4 resulted in increased MDA, nitric oxide, transaminases and decreased GSH and PON1 activity compared with the silymarin + cannabis treatment group. The histopathological studies confirmed these findings. The present results thus suggest decreased effectiveness of silymarin by cannabis administration.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms