The characterization of multi-component materials i.e. multi-element or multi-structure, in solids by analytical techniques is not straightforward because of the inherent characteristics of the different constituents. This task is more complex in materials used in additive manufacturing which may combine solid materials as diverse as organics, metals or ceramics. Unlike gas and liquid systems, solid multi-components usually lack homogeneity. This fact is an issue in the analysis and characterization of elemental and compositional features. For instance, analytical superficial measurements done to solids may lead to misinterpretation of the real composition of the bulk sample. Then, the selection of a technique that involves the bulk properties should solve that problem because all constituents are simultaneously studied. The next issue when designing a characterization process of multi-components is the selection of the property that both reflects some characteristic feature of the constituents and serves as a reference as well. Among many techniques, differential scanning calorimetry (DSC) is an outstanding example of analytical technique that summarizes simplicity and feasibility of measurement. This technique could be used to verify purity, heat of reaction, heat of formation, glass transition temperatures, crystallinity percent of a polymer and many other properties. In this work, the heat of formation is selected as a bulk property of the sample to be analytically obtained. Three alloys of composition Ce_0.52La_0.25Nd_0.17Pr_0.06, Ce_0.47La_0.33Nd_0.15Pr_0.05 and Ce_0.58La_0.16Nd_0.14Pr_0.08Y_0.04 are studied. The heat of formation of the respective multi-component lanthanide oxides is obtained by non-isothermal DSC at a heating ratio of 5 °C.min^-1 and in a flowing dry air atmosphere. The enthalpy changes i.e (DHf° kJ/mole) obtained by DSC is verified with measurements of the composition and structure of reactants and products of reaction done by transmission electron microscopy (TEM), x-rays diffraction (XRD) and energy dispersive spectroscopy (EDS). The results obtained show the advantages of using this DSC as an analytical technique to characterize solid multi-components used in additive manufacturing.