Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Toxicology   Volumes    Volume 16 
Astaxanthin ameliorated adenine-induced renal tubulointerstitial lesions
Ayumi Miyake, Kazuhiko Suzuki
Pages: 41 - 54
Number of pages: 14
Current Topics in Toxicology
Volume 16 

Copyright © 2020 Research Trends. All rights reserved

We examined the effect of astaxanthin (AST) on suppression of renal injury by improvement in intestinal flora in adenine-induced renal injury model. Histopathologically, moderate tubular damage and inflammatory cell infiltration were observed in 0.1% adenine-administrated group, and these changes were ameliorated by AST co-administration. In 0.2% adenine-administered group, renal injury became severer than 0.1% adenine-administered group and this was slightly ameliorated by AST co-administration. Positive reaction for HNF4α in the nuclei of tubular epithelial cells decreased in injured tubules which was recovered by AST co-administration. The number of CD3- and F4/80-positive cells increased by adenine administration and decreased by AST co-administration in both dose groups. Intestinal flora did not change by AST co-administration. The mRNA expression of inflammatory cytokines did not change by AST co-administration. In the present study, AST had some role in the anti-inflammatory effect, but not in the intestinal environment. Moreover, recovery of HNF4α in injured tubules indicated the amelioration of tubular injury by AST and the utility of HNF4α as a tubular injury marker. Based on the results of this experiment and other reports it was suggested that amelioration effect of AST on renal injury might be different according to the degree and quality of injury.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms