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Trends in Chemical Engineering   Volumes    Volume 17 
Biosurfactant production in a stirred-tank fermenter under mechanical foam control
Satoshi Takesono, Masayuki Onodera
Pages: 51 - 57
Number of pages: 7
Trends in Chemical Engineering
Volume 17 

Copyright © 2019 Research Trends. All rights reserved

Production of surfactin, a lipopeptide-type biosurfactant, requires mechanical foam control using a foam-breaking apparatus to cultivate Bacillus subtilis ATCC 21332 without addition of an anti-foaming agent. The amount of surfactin produced through such mechanical foam control was greater than that by chemical foam control with addition of the anti-foam agent under identical culture conditions. The surfactin production rate was increased by raising the iron ion concentration during the cell growth decline phase. In a stirred-tank fermenter with mechanical foam control, the overall surfactin production rate reached 40.3 mg/(hr·L) under conditions where the iron ion concentration was increased to 8 mM after 18 hr of culture. This production rate was 10.9 times that obtained without adding iron ion during the culture period.
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