Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 18 
Alternative pathways involved in the antinociceptive effect of Canavalia brasiliensis lectin: nitric oxide and the adrenergic system
Alana Freitas Pires, Benildo Sousa Cavada, Andrelina Noronha Coelho de Souza, Eva Pollyanna Peixe Laranjeira, João Batista Cajazeiras, Ana Maria Sampaio Assreuy, Cláudia Ferreira Santos
Pages: 45 - 49
Number of pages: 5
Current Topics in Pharmacology
Volume 18 

Copyright © 2014 Research Trends. All rights reserved

It has been demonstrated that the leguminous lectin isolated from Canavalia brasiliensis (ConBr), administered per oral to mice, exhibits peripheral and central antinociceptive effects mediated by the opioid system and the lectin domain. The objective of this study was to investigate the involvement of the correlated antinociceptive pathways, nitric oxide and adrenergic, in the oral effect of ConBr in the formalin test. Male Swiss mice were treated with ConBr (100 mg/kg; p.o.) before the formalin test in presence of the nitric oxide synthase substrate L-arginine (3.4 mmol/kg; i.p.), or the α1 adrenoceptor antagonist prazosin (0.4 µmol/kg; i.p.). Investigation of the L-arginine/NO pathway showed that the antinociceptive effect of ConBr (P1: 52.5 ± 4.18 s) was not altered by L-arginine (P1: 56.67 ± 9.33 s) in the first phase of the formalin test. However in the second phase the ConBr effect (P2: 73.5 ± 11.63 s) was partially inhibited by L-arginine (P2: 118.25 ± 11.08 s). Involvement of the adrenergic pathway showed that prazosin (P1: 71.16 ± 9.16 s; P2: 219.22 ± 15.92 s) did not alter the antinociceptive effect of ConBr in the first phase (P1: 57.88 ± 5.52 s), but blocked the lectin effect in the second phase (P2: 65.14 ± 8.13 s). In conclusion, ConBr administration per oral in mice elicits antinociceptive activity via L-arginine/NO and adrenergic pathways in the inflammatory phase of the formalin test.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms