Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Photochemistry & Photobiology   Volumes    Volume 18 
A ruthenium-based luminescent probe for differentiating amyloid beta aggregates through emission lifetime
Mariana P. Cali, Wallance M. Pazin, Amando S. Ito, Rose M. Carlos
Pages: 29 - 39
Number of pages: 11
Trends in Photochemistry & Photobiology
Volume 18 

Copyright © 2019 Research Trends. All rights reserved

A sensitive and selective strategy to identify and differentiate amyloid beta (Aβ) aggregates remains a challenge in amyloid protein research. Here we show that the luminescent complex cis-[Ru(phen)2 (3,4Apy)2]2+ (RuApy, 3,4APy = 3,4-diaminopyridine, phen = 1,10-phenanthroline) presents an unique sensitivity and selectivity to the aggregation process of Aβ1-40 and its Aβ1-28, Aβ11-22 and Aβ29-40 variants. The complex is a valuable probe for time-resolved imaging of Aβ aggregates, as it displays a long-lived emission without quenching the short-lived fluorescence of the peptide. Strikingly, these luminescence lifetime patterns are characteristic of the specific Aβ:complex interactions for Aβ1-28 (1.7 and 18.5 ns), Aβ11-22 (1.8 and 22.8 ns) and Aβ1-40 (2.8 and 7.4 ns), thereby enabling differentiation between Aβ peptide aggregates.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms