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Current Topics in Pharmacology   Volumes    Volume 19 
PAMFix, a fixative developed to enable remote platelet function testing: uses and applications
Stan Heptinstall, Sue Fox, Jane May, Ann White, Natalia Dovlatova
Pages: 1 - 12
Number of pages: 12
Current Topics in Pharmacology
Volume 19 

Copyright © 2015 Research Trends. All rights reserved

PAMFix is a fixative that was developed to stabilize the platelet biomarker P-selectin on activated platelets. Stabilization of this biomarker introduced the possibility of performing measurements of platelet function remotely where there was no access to special equipment or technical expertise. The idea was to use PAMFix to fix the platelets after stimulating platelets in blood, after which the stabilized samples would be transported to a central laboratory for analysis by flow cytometry. This would obviate the need for special equipment or technical expertise at or near the point at which the blood was collected and processed. Here we demonstrate the stability of samples of blood treated with PAMFix and describe several applications in which the use of PAMFix has proved to be particularly beneficial.
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