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Current Topics in Pharmacology   Volumes    Volume 19 
Evaluation of pathological status and drug effects using isolated pulmonary vein preparations
Hikaru Tanaka, Yayoi Tsuneoka, Masahiko Irie, Haruna Kanae, Yusuke Tanaka, Shogo Hamaguchi, Iyuki Namekata
Pages: 51 - 56
Number of pages: 6
Current Topics in Pharmacology
Volume 19 

Copyright © 2015 Research Trends. All rights reserved

The pulmonary vein contains a myocardial layer connected to the left atrial myocardium, which is currently receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Isolated pulmonary vein preparations show automaticity, which is the result of spontaneous electrical firing of the myocardial layer. The firing is dependent on depolarizing membrane currents enhanced by elevated intracellular Ca2+ concentration. The weak repolarizing power of the pulmonary vein myocardium plays a permissive role in the manifestation of automaticity. The electrophysiological properties of the isolated pulmonary vein reflect the pathological status of the animal and are sensitive to various pharmacological agents. Thus, the isolated pulmonary vein is useful for the studies on the mechanism of atrial fibrillation and the evaluation of drug effects.
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