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Trends in Organic Chemistry   Volumes    Volume 19 
Structure of O-alkyl-N-ethoxycarbonyl thiocarbamate and imidothiocarbonate derivatives
Vanina M. Cayón, Sonia E. Torrico Vallejos, Carlos O. Della Védova, Oscar E. Piro, Gustavo A. Etcheverría, Mauricio F. Erben
Pages: 43 - 73
Number of pages: 31
Trends in Organic Chemistry
Volume 19 

Copyright © 2018 Research Trends. All rights reserved

O-methyl-N-ethoxycarbonylthiocarbamate, CH3CH2OC(O)N(H)C(S)OCH3 (I), and O-ethyl-N-ethoxycarbonylthiocarbamate, CH3CH2OC(O)N(H)C(S)OCH2CH3 (II), were prepared by the addition reaction between CH3CH2OC(O)NCS and the corresponding alcohols. Their structural and conformational properties were studied using low-temperature single crystal X-ray diffraction and vibrational spectroscopy assisted by quantum chemical calculations. Compound I crystallizes in the monoclinic space group P21/n with lattice parameters a = 4.2450(1), b = 18.4992(5), c = 9.8759(3) Å, β = 95.887(3)° and 4 molecules per unit cell (Z=4), and II in the triclinic space group PĪ with parameters a = 4.1771(8), b = 9.235(2), c = 11.804(2) Å and crystallographic angles α = 98.17(1), β = 98.62(1), γ = 102.29(2)°, and Z = 2. In the crystal,the conformation around the thiocarbamate group-N(H)C(S)O- is characterizedby a synperiplanar orientation of the C=S double with respect to the N-H single bond, while the methoxycarbonyl C=O double bond is in antiperiplanar orientation with respect to the N-H bond. Both species form dimers linked by NH•••S=C hydrogen bond, the N•••S non-bonding distance being 3.352(2) Å in compound I. Furthermore, ethoxycarbonylimidothiocarbonate species were obtained by the addition of methyl and n-butyl groups to the C=S double bond of I and II. Thus, species with formula CH3CH2OC(O)N=C (SCH3)OCH3 (III), CH3CH2OC(O)N=C(SCH3)OCH2CH3 (IV), as well as the novel compounds CH3CH2OC(O)N=C(SC4H9)OCH3 (V) and CH3CH2OC(O)N=C(SC4H9)OCH2CH3 (VI), were also prepared and fully characterized by spectroscopic methods.
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