In the research and development of nuclear fusion, some functionalized materials have been widely applied to hydrogen isotopes (hydrogen, deuterium, and tritium) processing and/or handling techniques such as evacuation, recovery, storage, supply, purification, enrichment, and separation. Some getters have been already developed and applied to hydrogen isotope handling as well as impurity control in tokamaks. In this review, I have described the status of getter application: (1) plasma-vacuum conditioning, (2) storage-supply-recovery, (3) purification, enrichment and separation, and (4) removal and waste management. The improvement of getter properties, however, is required so as to apply them to a wider variety of the unit processes of the hydrogen isotope handling techniques. It has been pointed out that there is a need for investigations on (1) the activation-deactivation mechanisms, (2) adsorption-absorption-desorption properties and mechanisms, (3) durability and/or reactivity against impurity gases, (4) isotope effects, and (5) alloying effects. The fields such as hydrogen energy and battery require the functionalized materials for hydrogen processing and/or handling techniques such as generation, separation-purification-enrichment, and storage-supply. These storage and supply processes require the improvement of the properties on the hydrogen capacity at equilibrium and the kinetic rate of adsorption-absorption-desorption.