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Current Trends in Microbiology   Volumes    Volume 2 
Implementation of rapid colorimetric methods for drug resistance detection in M. tuberculosis: perspectives for low-resource settings
Juan Carlos Palomino, Anandi Martin
Pages: 75 - 83
Number of pages: 9
Current Trends in Microbiology
Volume 2 

Copyright © 2006 Research Trends. All rights reserved


It is estimated that one third of the world population is latently infected with Mycobacterium tuberculosis and drug resistance and multidrug resistance, defined as resistance to at least isoniazid (INH) and rifampicin (RIF), two critical drugs in the treatment of tuberculosis, is also of major concern for the control of the disease, stressing the need for early detection of drug resistant and multidrug resistant strains of M. tuberculosis. During the last decade several new approaches have been proposed for the early and rapid detection of drug resistant tuberculosis, many of them have relied on rapid molecular techniques that due to their cost and requirement for skilled personnel have not gained access yet to the clinical diagnostic laboratory, especially in developing countries where the situation of tuberculosis and multidrug resistance constitute a major problem. The present review will address several new colorimetric approaches recently proposed for the rapid detection of drug resistance in TB that due to their simplicity and low cost could constitute good alternatives for low-resource countries.

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