Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 20 
Angiotensin II, angiotensin II receptors and diabetes mellitus
Lilia Pashova-Stoyanova, Maria Ganeva
Pages: 99 - 111
Number of pages: 13
Current Topics in Pharmacology
Volume 20 

Copyright © 2016 Research Trends. All rights reserved

Angiotensin II (Ang II), the main effector of the renin-angiotensin system (RAS), is closely connected to insulin resistance, diabetes mellitus (DM) and its complications. Ang II carries out its effects mainly through the activation of AT1 and AT2 receptor subtypes. The signal transduction mechanisms of the AT1 receptor typically depend on phospholipase C (PLC), phospholipase D (PLD), phospholipase A2 (PLA2) and adenylyl cyclase while AT2 receptor signaling is linked to protein phosphatases and activation of nitric oxide/cGMP system. AT1 receptor activation is associated with vasoconstriction, growth, and inflammation whereas AT2 receptor activation leads to vasodilation, anti-inflammatory, and proapoptotic action. RAS contributes to insulin resistance and endothelial dysfunction in DM through the modulation of insulin signaling. It is hypothesized that in DM AT2 receptors are down regulated thus leaving AT1 receptors unopposed. The disbalance between AT1 and AT2 receptor-mediated signaling and the rise in Ang II levels lead to an increase in blood pressure, renal cell proliferation and hypertrophy, stimulation of reactive oxygen species and insulin resistance. Association of AT receptor gene polymorphisms and DM and its complications in different patient populations have been investigated.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms