Atopy is a medical term for many allergies. When a person has many allergies, a diverse number of immunoglobulin-e antibodies eliminate harmless exogenous-proteins referred to as allergens. The immunoglobulin-e antibodies formed through humoral immunity can bind to endogenous proteins based on structure homology, a cross-react immune response. An over-expression of endogenous proteins is associated with aggressive blood cancer, including leukemia, lymphoma, and myeloma. Cancer immunotherapies seek to stop or inhibit the growth of blood cancer cells. This review proposes cancer immunotherapy involving allergen-specific proteins wherein a hyper-allergenic skin cream induces immunoglobulin-e antibodies that may cross-react with over-expressed proteins associated with acute myeloid leukemia.
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