Translation is a step of protein synthesis where the messenger ribonucleic acid (mRNA) sequence is decoded and translated into a sequence of amino acids, forming a polypeptide to execute various cellular functions. Earlier observations have revealed that the rate of translation is not uniform and dependent on various factors, mostly the availability of the corresponding transfer RNA (tRNA)-bound amino acid molecules. When there is a scarcity in the tRNA in need, the translation will pause, and the immature peptide was thought to be lysed. In this current research, a literature search on “translational pause”, “ribosome pause”, or “ribosomal pause” on Pubmed, Google Scholar, and Embase was performed. The findings indicate that more recent evidence is supporting the argument that this translational pause does actually have biological functions and is tediously fine-tuned, which will be discussed later in this short communication. Despite receiving little scientific interest, translational pause may be a novel realm of molecular biology to be explored and acts as a key to understand many misfolding-protein diseases, such as Alzheimer’s disease, amyloidosis, and Parkinson’s disease, among others.
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