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Trends in Organic Chemistry   Volumes    Volume 22 
Abstract
Synthesis of substituted pyrazolo[3,4-b]pyridine
Salha Hamri, El-Mahdi Ourhzif, Asmaa Oumessaoud, Jabrane Jouha, Hasna Yassine, Jamila Bouali, Abderrafia Hafid, Mostafa Khouili, Maria Dolors Pujol
Pages: 39 - 51
Number of pages: 13
Trends in Organic Chemistry
Volume 22 

Copyright © 2021 Research Trends. All rights reserved

ABSTRACT
 
A convenient route has been developed for the synthesis of new nitrogenous heterocyclic compounds containing the subastpyrazolo[3,4-b]pyridine nucleus, by condensation reaction of 5-amino-3-methyl-1-phenyl-1H-pyrazole (1) with 4-hydroxy-6-methylpyran-2-one (2). Various reaction conditions were carefully studied. The reaction depends on the solvent used and when it is acetic acid a mixture of 3 and 5 is formed. Pyrazolopyridine 3 was obtained with better yields when the condensation of 2 and 1 was carried out using methanol as a solvent and with the presence of p-toluene sulfonic acid (PTSA) and assisted by microwave irradiation.
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