Immunosensors are biosensors based on the interaction between antibodies and antigens on the transducer surface. The use of immunosensors is a promising method for detecting pathogens, including viral pathogens. This is because antibodies are natural receptors in binding harmful antigens to an organism so that they have high selectivity and natural binding efficiency. Hepatitis B infection is an infectious disease caused by the hepatitis B virus (HBV). This review focuses on the use of electrochemical immunosensors, both labeled and unlabeled, reported in the last three years for the detection of hepatitis B antigen (HBsAg) and hepatitis B e antigen (HBeAg) as biomarkers of hepatitis B viruses’ infection. The principle of detection and the limit of detection of the developed electrochemical immunosensors are reported in this review.
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